Product Details

Purity

≥ 95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 at 2 μg/mL can bind Anti-SEZ6 recombinant antibody (CSB-RA684467MA1HU). The EC50 is 2.324-2.770 ng/mL.

Target Names

SEZ6

Uniprot No.

Q53EL9

Alternative Names

Seizure protein 6 homolog; SEZ-6; hSEZ-6; SEZ6

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

20-925aa

Target Protein Sequence

LSLEAPTVGKGQAPGIEETDGELTAAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAH

Mol. Weight

99.1 kDa

Protein Length

Partial

Tag Info

C-terminal 10xHis-tagged

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

SEZ6 plays a critical role in neuronal membrane trafficking and synapse formation, making it a valuable target for investigating neurodevelopmental and neurodegenerative mechanisms. This partial extracellular construct spanning residues 20–925 demonstrates quantifiable binding activity with an EC50 of 2.324–2.770 ng/mL against an anti-SEZ6 recombinant antibody in functional ELISA, providing a validated basis for ligand-binding assays, therapeutic antibody epitope mapping, and competitive inhibition screening. Mammalian cell expression preserves the native glycosylation and disulfide bond patterns essential for conformational integrity in receptor-ligand interaction studies, including surface plasmon resonance and biolayer interferometry experiments. The protein meets quality thresholds commonly required for antibody validation workflows, with purity exceeding 95% by SDS-PAGE and endotoxin levels below 1.0 EU/μg, supporting its use as a positive control in binding assays and drug discovery campaigns targeting SEZ6-mediated pathways.

Code	CSB-MP684467HU2
Abbreviation	Recombinant Human SEZ6 protein, partial (Active)
MSDS	MSDS Datasheet
Size	$138
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Activity Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 at 2 μg/ml can bind Anti-SEZ6 recombinant antibody (CSB-RA684467MA1HU). The EC₅₀ is 2.324-2.770 ng/mL. Biological Activity Assay
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Recombinant Human Seizure protein 6 homolog (SEZ6), partial (Active)

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