SEZ6

SEZ6, a protein encoded by the SEZ6 gene on chromosome 17q11.2, is a key member of the SEZ6 family that plays a vital role in the nervous system's development and function. It contributes to the formation of neural dendrites and the transmission of neural signals, with its structure featuring five Sushi domains and two to three CUB domains that are involved in protein-protein interactions and may modulate intercellular adhesion or neurotransmitter receptor regulation. SEZ6 also interacts with the complement system, potentially inhibiting it by promoting factor I cleavage of C3b and accelerating the decay of C3 convertase. Its high expression is linked to tumor development and metastasis, especially in neuroendocrine tumors, making SEZ6 a potential therapeutic target for cancer treatment. In summary, SEZ6's roles in neural function and its association with cancer highlight its importance in both neurological health and oncology, offering insights for the development of new cancer treatment strategies.