SEZ6 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA684467MA1HU
Size	US$210
	Order now
Image	The Binding Activity of Cynomolgus SEZ6 with Anti-SEZ6 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus SEZ6 (CSB-MP6419MOV) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC₅₀ is 0.6865-1.065 ng/mL. The Binding Activity of Human SEZ6 with Anti-SEZ6 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 (CSB-MP684467HU2) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC₅₀ is 2.324-2.770 ng/mL.
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q53EL9

Target Names

SEZ6

Alternative Names

Seizure protein 6 homolog (SEZ-6) (hSEZ-6), SEZ6

Species Reactivity

Human, Cynomolgus

Immunogen

Recombinant Human SEZ6 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

12H9

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Recommended Dilution

Application	Recommended Dilution
ELISA	1:5000-1:50000

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

SEZ6, or Seizure protein 6 homolog, is a transmembrane protein predominantly expressed in the brain where it plays important roles in neuronal development, synapse formation, and motor coordination. This target has garnered significant research interest due to its implications in neurodevelopmental processes and its potential involvement in neurological disorders, making it a compelling focus for both basic neuroscience research and translational studies.

This recombinant monoclonal antibody, clone 12H9, offers researchers the reproducibility and consistency that sequence-defined recombinant technology provides. Unlike traditional hybridoma-derived antibodies, each lot delivers identical performance characteristics, eliminating the variability that can compromise long-term studies or multi-site collaborations. The antibody is produced with a human IgG1 isotype and undergoes affinity chromatography purification to ensure high purity and reliable performance.

Functional ELISA validation demonstrates robust binding activity against both human and cynomolgus monkey SEZ6 proteins. Testing with immobilized human SEZ6 yielded an EC50 of 2.324–2.770 ng/mL, while cynomolgus SEZ6 showed even higher sensitivity with an EC50 of 0.6865–1.065 ng/mL. This cross-species reactivity is particularly valuable for researchers conducting preclinical studies where cynomolgus models serve as translational bridges to human biology. The recommended ELISA dilution range of 1:5000 to 1:50000 provides flexibility to optimize signal intensity based on specific experimental conditions.

Supplied in a stabilized liquid format containing glycerol and PBS with Proclin 300 preservative, this antibody is ready for immediate use in ELISA-based detection workflows investigating SEZ6 biology in neurological research contexts.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity.

Gene References into Functions

The human SEZ-6 gene is related to the occurrence and development of FS and may be a novel candidate gene for epilepsy. Screening for mutations in SEZ-6 may be valuable in predicting FS recurrence or the development of epilepsy. PMID: 17086543

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

SEZ6 family

Database Links

HGNC: 15955

OMIM: 616666

KEGG: hsa:124925

UniGene: Hs.21837

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

SEZ6: A New Therapeutic Target for Neuroendocrine Tumors with Multiple ADCs in Clinical Development Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

No. 269, Shendun 5th Road, Donghu Hi-Tech Development Area, Hubei Province, 430206, P.R.China

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
Please enter the characters shown. Click the image to refresh if unclear.

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address