Recombinant Macaca mulatta Microtubule-associated protein tau (MAPT) (Active)

Tau protein plays a central role in neurodegenerative tauopathies, and this rhesus macaque MAPT provides a translationally relevant ortholog for primate-focused neuroscience research. Produced in a mammalian expression system, this full-length mature protein (aa 2–459) carries an N-terminal 10×His tag and demonstrates confirmed binding activity in a functional ELISA, where immobilized MAPT at 2 μg/mL engaged an anti-MAPT recombinant antibody with an EC₅₀ of 2.464–3.979 ng/mL — supporting direct use in antibody characterization, epitope mapping, and sandwich ELISA development. The endotoxin level below 1.0 EU/μg, combined with greater than 95% purity by SDS-PAGE, satisfies the quality criteria typical for cell-based tau aggregation assays and functional studies examining microtubule binding dynamics. This protein provides a suitable basis for researchers developing cross-species reactive antibodies or investigating tau pathology in non-human primate models of Alzheimer's disease.