ACSL1 Antibody

Code CSB-PA001191GA01HU
Size US$685
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No. P33121
Target Names ACSL1
Alternative Names ACS 1 antibody; ACS1 antibody; ACSL 1 antibody; ACSL1 antibody; ACSL1_HUMAN antibody; Acyl CoA synthetase 1 antibody; Acyl CoA synthetase long chain family member 1 antibody; Acyl-CoA synthetase 1 antibody; FACL 1 antibody; FACL 2 antibody; FACL1 antibody; FACL2 antibody; Fatty acid Coenzyme A ligase long chain 1 antibody; Fatty acid Coenzyme A ligase long chain 2 antibody; LACS 1 antibody; LACS 2 antibody; LACS antibody; LACS1 antibody; LACS2 antibody; Lignoceroyl CoA synthase antibody; Long chain acyl CoA synthetase 1 antibody; Long chain acyl CoA synthetase 2 antibody; Long chain fatty acid CoA ligase 1 antibody; Long chain fatty acid CoA ligase 2 antibody; Long chain fatty acid coenzyme A ligase 1 antibody; Long-chain acyl-CoA synthetase 1 antibody; Long-chain acyl-CoA synthetase 2 antibody; Long-chain fatty acid-CoA ligase 2 antibody; Long-chain-fatty-acid--CoA ligase 1 antibody; Palmitoyl CoA ligase 1 antibody; Palmitoyl CoA ligase 2 antibody; Palmitoyl-CoA ligase 1 antibody; Palmitoyl-CoA ligase 2 antibody; Paltimoyl CoA ligase 1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human ACSL1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Background

Function
(From Uniprot)
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Gene References into Functions
  1. These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients. PMID: 28498416
  2. Study identified a genetic variant in the 3'-UTR region of ACSL1 gene (rs8086) that may play a significant role in predicting outcomes of stage II/III patients with colon cancer, so that patients with T/T genotype had a significantly higher risk of tumor recurrence than those carrying at least one C allele. PMID: 27992526
  3. The mRNA levels of ACSL1 were positively associated with those of HBXIP in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP is able to up-regulate ACSL1 through activating the transcriptional factor Sp1 in breast cancer. PMID: 28132807
  4. evidence in humans of ACSL1 SNPs associated with fasting glucose, diabetes, and subclinical atherosclerosis PMID: 26711138
  5. SRE motif in ACSL1 is essential for SREBP2-mediated activation of C-ACSL1 gene transcription. PMID: 26728456
  6. ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. PMID: 25915184
  7. the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
  8. Data indicate that expression of miR-205 is negatively related to that of ACSL1 in clinical hepatocellular carcinoma (HCC) tissues. PMID: 24462768
  9. long-chain acyl-CoA synthetase 1 has a role in eicosapentaenoic acid suppression of palmitate-induced cytokine production PMID: 23433401
  10. Findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population. PMID: 22829935
  11. Data show that ACSL1 rs9997745 polymorphism influences metabolic syndrome risk, most likely via disturbances in fatty acid metabolism, which was modulated by dietary fat consumption, particularly PUFA intake, suggesting novel gene-nutrient interactions. PMID: 20176858
  12. Based on homology, two new isoforms for ACSL1 were predicted and characterized, one represented a switch of the Phe- to the Tyr-Gate domain motif, the other resulted from the exclusion of both. PMID: 16834775

Show More

Hide All

Subcellular Location Mitochondrion outer membrane, Single-pass type III membrane protein, Peroxisome membrane, Single-pass type III membrane protein, Microsome membrane, Single-pass type III membrane protein, Endoplasmic reticulum membrane, Single-pass type III membrane protein
Protein Families ATP-dependent AMP-binding enzyme family
Tissue Specificity Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
Database Links

HGNC: 3569

OMIM: 152425

KEGG: hsa:2180

STRING: 9606.ENSP00000281455

UniGene: Hs.406678

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1