AFF2 Antibody

Code CSB-PA001413LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: A549 whole cell lysate
    All lanes: AFF2 antibody at 5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 145, 141, 48, 144, 106 kDa
    Observed band size: 145 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AFF2 Polyclonal antibody
Uniprot No.
Target Names
AFF2
Alternative Names
AF4/FMR2 family member 2 antibody; AF4/FMR2 family, member 2 antibody; AFF2 antibody; AFF2_HUMAN antibody; FMR2 antibody; FMR2P antibody; Fragile X E mental retardation syndrome protein antibody; fragile X mental retardation 2 antibody; Fragile X mental retardation 2 protein antibody; fragile X mental retardation gene associated with FRAXE antibody; FRAXE antibody; mild or borderline mental retardation antibody; MRX2 antibody; OTTHUMP00000024204 antibody; OX19 antibody; Protein FMR-2 antibody; Protein Ox19 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human AF4/FMR2 family member 2 protein (575-705AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The AFF2 Antibody (Product code: CSB-PA001413LA01HU) is Non-conjugated. For AFF2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001413LB01HU AFF2 Antibody, HRP conjugated ELISA
FITC CSB-PA001413LC01HU AFF2 Antibody, FITC conjugated
Biotin CSB-PA001413LD01HU AFF2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
Gene References into Functions
  1. Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia. PMID: 25256661
  2. FMR2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of ID- and FRAXE-associated ID in particular. PMID: 23562910
  3. 2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites. PMID: 22773736
  4. A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X E in a small subset of patients. PMID: 22065534
  5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300

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Involvement in disease
Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE)
Subcellular Location
Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles.
Protein Families
AF4 family
Tissue Specificity
Brain (most abundant in hippocampus and amygdala), placenta and lung.
Database Links

HGNC: 3776

OMIM: 300806

KEGG: hsa:2334

STRING: 9606.ENSP00000359489

UniGene: Hs.496911

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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