AFF2 Antibody

Datasheet

Code	CSB-PA114461
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA114461(AFF2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA114461(AFF2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal lung tissue, Primary antibody: CSB-PA114461(AFF2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

P51816

Target Names

AFF2

Alternative Names

AF4/FMR2 family member 2 antibody; AF4/FMR2 family, member 2 antibody; AFF2 antibody; AFF2_HUMAN antibody; FMR2 antibody; FMR2P antibody; Fragile X E mental retardation syndrome protein antibody; fragile X mental retardation 2 antibody; Fragile X mental retardation 2 protein antibody; fragile X mental retardation gene associated with FRAXE antibody; FRAXE antibody; mild or borderline mental retardation antibody; MRX2 antibody; OTTHUMP00000024204 antibody; OX19 antibody; Protein FMR-2 antibody; Protein Ox19 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human AFF2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.

Gene References into Functions

Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia. PMID: 25256661
FMR2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of ID- and FRAXE-associated ID in particular. PMID: 23562910
2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites. PMID: 22773736
A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X E in a small subset of patients. PMID: 22065534
overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300

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Involvement in disease

Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE)

Subcellular Location

Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles.

Protein Families

AF4 family

Tissue Specificity

Brain (most abundant in hippocampus and amygdala), placenta and lung.

Database Links

HGNC: 3776

OMIM: 300806

KEGG: hsa:2334

STRING: 9606.ENSP00000359489

UniGene: Hs.496911

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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