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AKR1B10 Antibody

Datasheet
Code CSB-PA001540ESR2HU
Size US$166
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Image
  • Western Blotting(WB) - AKR1B10 Antibody

    Western blot
    All lanes: AKR1B10 antibody at 4µg/ml + A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 36 kDa
    Observed band size: 36 kDa

  • Immunohistochemistry(IHC) 1- AKR1B10 Antibody

    Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001540ESR2HU at dilution of 1:100

  • Immunohistochemistry(IHC) 2- AKR1B10 Antibody

    Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001540ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) AKR1B10 Polyclonal antibody
Uniprot No.
O60218
Target Names
AKR1B10
Alternative Names
AK1BA_HUMAN antibody; AKR1B10 antibody; AKR1B11 antibody; AKR1B12 antibody; Aldo keto reductase family 1 member B10 antibody; aldo keto reductase family 1 member B11 antibody; Aldo-keto reductase family 1 member B10 (aldose reductase) antibody; Aldo-keto reductase family 1 member B10 antibody; Aldo-keto reductase family 1 member B11 (aldose reductase-like) antibody; aldose reductase like 1 antibody; Aldose reductase like antibody; aldose reductase like peptide antibody; Aldose reductase related protein antibody; Aldose reductase-like antibody; Aldose reductase-related protein antibody; ALDRLn antibody; ARL 1 antibody; ARL-1 antibody; ARL1 antibody; ARL1 Human small intestine reductase antibody; ARP antibody; hARP antibody; HIS antibody; HSI antibody; SI reductase antibody; Small intestine reductase antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Aldo-keto reductase family 1 member B10 protein (1-316AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:1000
IHC 1:20-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

CUSABIO generates the AKR1B10 antibody through the immunization of rabbits with the recombinant human AKR1B10 protein (1-316AA) and subsequent antigen affinity purification from rabbit antiserum. It is available as an unconjugated IgG. It is only reactive with human AKR1B10 protein, which mediates the detoxification of reactive aldehydes in digested food before nutrients are distributed to other organs and interferes with cell survival by modulating lipid synthesis, mitochondrial function, and oxidative status. This anti-AKR1B10 antibody has been validated for use in ELISB, IHC, and WB applications.

Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.
Gene References into Functions
  1. Immunohistochemistry showed that the expression of AKR1B10 was increased in tumor tissue from patients with early-stage HCC. PMID: 30328412
  2. These results suggest that AKR1B10 is involved in HBV-related hepatocarcinogenesis, but its high expression could predict low risk of early tumor recurrence in patients with HBV-related hepatocellular carcinoma (HCC)after liver resection. PMID: 28181486
  3. AKR1B10 is upregulated in mucinous cystic pancreatic tumors and may be used to improve non-operative diagnosis. PMID: 29079172
  4. A combined gene expression signature of AKR1B10 (low) and AKR1B1 (high) showed a better prognostic stratification of CRC patients independent of confounding factors. PMID: 28929377
  5. Our study demonstrated not only the dysfunction of the AKR1B10 gene in lipid metabolizing but also its important role in the overproliferation and migration of keratinocyte, which provided evidence for further therapeutic uses for psoriasis. PMID: 29204449
  6. Data show that cells with higher levels of aldo-keto reductases AKR1B1 and/or AKR1B10 (AKR1Bs) were more sensitive to 2-deoxyglucose (2DG). PMID: 29617059
  7. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples. PMID: 29383608
  8. AKR1B10 overexpression is an independent poor prognostic biomarker for oral squamous cell carcinoma. PMID: 28301069
  9. These data suggest that AKR1B10 promotes breast cancer metastasis PMID: 27248472
  10. Several antioxidant response elements-like sequences in the 5'-flanking region up to -3282 bp of the AKR1B10 gene plays an important role in AKR1B10 gene regulation by various Nrf2-mediating stimuli. PMID: 28219640
  11. This study presents novel evidence that AKR1B10 protects colon cells from DNA damage induced by electrophilic carbonyl compounds. PMID: 26969882
  12. the highly efficient, retinaldehyde-specific aldo-keto reductase enzyme AKR1B10 is up-regulated in keloid epidermis(KE) and its induced overexpression in normal skin keratinocytes affects the classical RA pathway, recreating KE expression patterns PMID: 27025872
  13. Data suggest that expression of STAR (steroidogenic acute regulatory protein) and AKR1B10 (aldo-keto reductase family 1, member B10) is down-regulated in high-grade versus low-grade endometrial tumors; expression of AKR1B10 correlates with body mass index, with up-regulation of expression of AKR1B10 in obese patients with endometrial tumors. PMID: 28232277
  14. Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 and a structurally similar isoform AKR1B1. PMID: 28003428
  15. Chronic hepatitis C patients expressing high levels of hepatic AKR1B10 had an increased risk of HCC development even after sustained virological response PMID: 27672277
  16. Various degrees of AKR1B10 upregulation in the liver were observed in patients with chronic HCV infection, and high AKR1B10 expression could be a novel pre- dictor of HCC. PMID: 26758591
  17. AKR1B10 is up-regulated with cisplatin resistance in gastrointestinal cancer cells. PMID: 27417252
  18. AKR1B10 mRNA and protein levels were higher in primary hepatocellular carcinoma (PHC) tissues than in peri-tumor tissues. PMID: 26948042
  19. AKR1B10 is overexpressed in nasopharyngeal hyperplasia, benign tumors, and carcinomas, being a potential new biomarker. PMID: 26835713
  20. Even at early stages of malignant transformationa considerable increase in AKR1B10 mRNA content was observed in 80% of tumors PMID: 27239845
  21. It would appear that hepatitis C virus infection alone increases AKR1B10 expression, which manifests itself as enhanced urinary excretion of polyols with reduced urinary excretion of their corresponding hexoses. PMID: 25487531
  22. Our data suggest that genetic variants in the AKR1B10 locus may influence human eating behavior. PMID: 25887478
  23. The three-dimensional structure of AKR1B10 with sulindac. PMID: 25532697
  24. The co-introduction of the c-Jun protein resulted in a decrease in the mRNA levels and promoter activity of AKR1B10. PMID: 25463304
  25. Autophagy and AKR1B10 contribute to the defense system. PMID: 25289770
  26. AKR1B10 is a doxorubicin-resistance gene in the gastric cancer cells, and is responsible for elevating the migrating and invasive potentials of the cells through induction of MMP2. PMID: 25686905
  27. Upregulation of AKR1B10 is associated with cisplatin resistance in lung cancer. PMID: 25156503
  28. AKR1B10 is a unique enzyme involved in pancreatic carcinogenesis via modulation of the Kras-E-cadherin pathway. PMID: 25304374
  29. AKR1B10 may have an important role in the development and progression of diabetic nephropathy. PMID: 23975544
  30. A significant correlation between the expression of AKR1B10 mRNA and protein levels as well as AKR1B10 copy number was observered, which suggest that AKR1B10 may play a role in AFB1-related hepatocarcinogenesis. PMID: 24391771
  31. Results suggest that decreased expression of AKR1B10 could disrupt the tumor suppressive function of p53, which result in decreased survival in colorectal cancer patients. PMID: 24140838
  32. AKR1B10, a member of Aldo-keto reductase family, was shown to be abundantly located in the filtering cells among a catalog of proteins.in ducal carcinoma of the breast. PMID: 23912490
  33. AKR1B10 is a unique biomarker involved in hepatocellular carcinogenesis PMID: 24656094
  34. AKR1B10 protein gene expression is a valuable indicator in patients diagnosed with gastric cancer. PMID: 24406159
  35. Lys-233, Glu-236, and Lys-240 in helix 10 mediate interaction of AKR1B10 with HSP90alpha and regulate AKR1B10 secretion. PMID: 24217247
  36. A hydrogen bond stabilized active site tryptophan conformation restricts inhibitor access in AKR1B1 compared with the more open AKR1B10 active site. PMID: 24100137
  37. our data suggest that post-chemotherapy AKR1B10 expression may be associated with a poor prognosis in patients who received carboplatin-gemcitabine combination chemotherapy and underwent cystectomy PMID: 22198799
  38. The gene expression of AKR1B10 at the mRNA level was significantly increased. PMID: 23146748
  39. AKR1B10 was the most efficient catalyst of the stoichiometric two-electron reduction of BQ. PMID: 22498646
  40. AKR1B10 was up-regulated in association with serum alpha-fetoprotein, and was an independent risk factor for hepatocellular carcinoma in chronic hepatitis C patients. PMID: 22681639
  41. AKR1B10 is a unique enzyme involved in pancreatic carcinogenesis possibly via modulation of cell apoptosis and protein prenylation. PMID: 22222635
  42. results suggest that AKR1B10 is up-regulated by EGF and insulin through AP-1 mitogenic signalling and may be implicated in hepatocarcinogenesis PMID: 22329800
  43. AKR1B10 overexpression is a prominent feature in both hereditary and sporadic papillary renal cell carcinoma and is upregulated in cell lines carrying a fumarate hydratase mutation. PMID: 22014576
  44. AKR1B10 might promote proliferation, inhibit apoptosis and induce malignant transformation of hepatocytes by regulating the expression level of some tumor-related genes. PMID: 20943077
  45. Confirm prognostic value of AKR1B10 in hepatocellular carcinoma and conclude that high expression reflects less aggressive tumour behaviour. PMID: 21645211
  46. High AKR1B10 secretion is associated with neoplasms. PMID: 21585341
  47. AKR1B10 is associated with smoking and smoking-related non-small-cell lung cancer. PMID: 21672310
  48. the enzyme activity of AKR1B10 and AKR1B1 toward alpha, beta-unsaturated carbonyl compounds with cellular and dietary origins PMID: 21329684
  49. Nrf2 is one of the major factors involved in the AKR1B10 gene regulation PMID: 21277289
  50. overexpression and silencing of AKR1B10 decreased and increased, respectively, susceptibility to cytotoxic effects of MMC and 4-hydroxy-2-nonenal, which was formed as a product of lipid peroxidation by MMC treatment. PMID: 21317765

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Subcellular Location
Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway.
Protein Families
Aldo/keto reductase family
Tissue Specificity
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Database Links

HGNC: 382

OMIM: 604707

KEGG: hsa:57016

STRING: 9606.ENSP00000352584

UniGene: Hs.116724

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