ALKBH5 Antibody

Code CSB-PA001611GA01HU
Size US$685
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Product Details

Uniprot No. Q6P6C2
Target Names ALKBH5
Alternative Names ALKBH5 antibody; ABH5 antibody; OFOXD1RNA demethylase ALKBH5 antibody; EC 1.14.11.53 antibody; Alkylated DNA repair protein alkB homolog 5 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human ALKBH5
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Dioxygenase that demethylates RNA by oxidative demethylation
Gene References into Functions
  1. Overexpression of ALKBH5 in MIA-PaCa-2 and BxPC-3 cells, demonstrats that ALKBH5 could inhibit cell migration and invasion and ALKBH5 inhibits cell motility by demethylating and increasing expression of KCNK15- AS1. PMID: 30032148
  2. N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A-recognising proteins, including FTO and ALKBH5. PMID: 27156733
  3. ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice PMID: 27590511
  4. ALKBH5-FOXM1 pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients. PMID: 28344040
  5. HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment PMID: 27001847
  6. The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population. PMID: 26047305
  7. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. PMID: 24778178
  8. Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms. PMID: 24489119
  9. findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB members PMID: 24616105
  10. ALKBH5 is a RNA demethylase and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells. PMID: 23177736
  11. ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene PMID: 21264265

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Subcellular Location Nucleus speckle
Protein Families AlkB family
Tissue Specificity Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
Database Links

HGNC: 25996

OMIM: 613303

KEGG: hsa:54890

STRING: 9606.ENSP00000382091

UniGene: Hs.744130

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