ANGPTL7 Antibody

Code CSB-PA001715LA01HU
Size US$166
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  • Western blot
    All lanes: ANGPTL7 antibody at 2µg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: Colo320 whole cell lysate
    Lane 3: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa

  • Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA001715LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA001715LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ANGPTL7 Polyclonal antibody
Uniprot No.
Target Names
ANGPTL7
Alternative Names
Angiopoietin like 7 antibody; Angiopoietin like factor (CDT6) antibody; Angiopoietin like factor antibody; Angiopoietin related protein 7 antibody; Angiopoietin-like factor antibody; Angiopoietin-like protein 7 antibody; Angiopoietin-related protein 7 antibody; ANGL7_HUMAN antibody; ANGPTL7 antibody; AngX antibody; CDT6 antibody; Cornea derived transcript 6 protein antibody; Cornea-derived transcript 6 protein antibody; dJ647M16.1 antibody; OTTHUMP00000001986 antibody; RP4-647M16.2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Angiopoietin-related protein 7 protein (27-296AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ANGPTL7 Antibody (Product code: CSB-PA001715LA01HU) is Non-conjugated. For ANGPTL7 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001715LB01HU ANGPTL7 Antibody, HRP conjugated ELISA
FITC CSB-PA001715LC01HU ANGPTL7 Antibody, FITC conjugated
Biotin CSB-PA001715LD01HU ANGPTL7 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The ANGPTL7 antibody is a polyclonal antibody generated in rabbits by immunization with recombinant human ANGPTL7 protein consisting of amino acids 27-296. This antibody is capable of detecting ANGPTL7 in human samples, indicating its specificity for this target protein. The ANGPTL7 antibody has been purified using Protein G, resulting in a purity of greater than 95%.

The ANGPTL7 polyclonal antibody is a valuable tool for researchers interested in studying the role of ANGPTL7 in human physiology and disease. It has validated validity in ELISA, WB, and IHC applications, increasing its versatility in experimental settings.

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Target Background

Function
Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency.
Gene References into Functions
  1. obesity increases the level of ANGPTL7 in both plasma and adipose tissue. Increased expression of ANGPTL7 might play a minor role in the regulation of TG level in obese subjects either directly or through interaction with other ANGPTL protein members. Physical exercise reduced the level of ANGPTL7 highlighting the potential for targeting this protein as a therapeutic target for regulating dyslipidemia. PMID: 28264047
  2. ANGPTL7, which is abundantly expressed in keratocytes, plays a major role in maintaining corneal avascularity and transparency. PMID: 25622036
  3. ANGPTL7 is markedly down regulated in metastatic liver cancer. PMID: 25854806
  4. Angiopoietin-like 7 is a novel pro-angiogenetic factor over-expressed in cancer PMID: 24903490
  5. Together with previous findings, these properties strengthen ANGPTL7's candidacy for the regulation of intraocular pressure and glaucoma. PMID: 21199193
  6. Induction of ANGPTL7 secretion by glaucoma stimuli and increased concentration of ANGPTL7 in glaucomatous AH suggest that ANGPTL7 is overexpressed in glaucoma. PMID: 18421092

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Subcellular Location
Secreted.
Tissue Specificity
Higly expressed in the cornea (at protein level). Expression is restricted to the stromal layer. Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera.
Database Links

HGNC: 24078

KEGG: hsa:10218

STRING: 9606.ENSP00000366015

UniGene: Hs.146559

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