ARPC3 Antibody

Datasheet

Code	CSB-PA03324A0Rb
Size	US$166
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Image	Western blot All lanes: ARPC3 antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 21 kDa Observed band size: 75 kDa Immunohistochemistry analysis of human testis tissue using CSB-PA03324A0Rb at dilution of 1:100 Immunohistochemistry analysis of human tonsil tissue using CSB-PA03324A0Rb at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA03324A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ARPC3 Polyclonal antibody

Uniprot No.

O15145

Target Names

ARPC3

Alternative Names

ARPC3 antibody; ARC21Actin-related protein 2/3 complex subunit 3 antibody; Arp2/3 complex 21 kDa subunit antibody; p21-ARC antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Actin-related protein 2/3 complex subunit 3 protein (2-175AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ARPC3 Antibody (Product code: CSB-PA03324A0Rb) is Non-conjugated. For ARPC3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03324B0Rb	ARPC3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA03324C0Rb	ARPC3 Antibody, FITC conjugated
Biotin	CSB-PA03324D0Rb	ARPC3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

Gene References into Functions

Cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo. PMID: 27748747
genetic association study in population in Canada: Data suggest that an SNP in the promoter region of ARPC3 (CpG-SNP rs3759384 C>T) is associated with metabolic syndrome complicated by severe abdominal obesity and hypertriglyceridemia in the population studied. PMID: 27055012
Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells. PMID: 21251247
The actin-related protein 3 structures were more visible with anti-p34Arc monoclonal antibody. PMID: 15793564

Subcellular Location

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Protein Families

ARPC3 family

Database Links

HGNC: 706

OMIM: 604225

KEGG: hsa:10094

STRING: 9606.ENSP00000228825

UniGene: Hs.524741

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Regulation of actin cytoskeleton Fc gamma R-mediated phagocytosis Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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