ARPC3 Antibody

Code CSB-PA03324A0Rb
Size US$166
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  • Western blot
    All lanes: ARPC3 antibody at 2µg/ml + 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 21 kDa
    Observed band size: 75 kDa

  • Immunohistochemistry analysis of human testis tissue using CSB-PA03324A0Rb at dilution of 1:100

  • Immunohistochemistry analysis of human tonsil tissue using CSB-PA03324A0Rb at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA03324A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ARPC3 Polyclonal antibody
Uniprot No.
Target Names
ARPC3
Alternative Names
ARPC3 antibody; ARC21Actin-related protein 2/3 complex subunit 3 antibody; Arp2/3 complex 21 kDa subunit antibody; p21-ARC antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Actin-related protein 2/3 complex subunit 3 protein (2-175AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ARPC3 Antibody (Product code: CSB-PA03324A0Rb) is Non-conjugated. For ARPC3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA03324B0Rb ARPC3 Antibody, HRP conjugated ELISA
FITC CSB-PA03324C0Rb ARPC3 Antibody, FITC conjugated
Biotin CSB-PA03324D0Rb ARPC3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Gene References into Functions
  1. Cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo. PMID: 27748747
  2. genetic association study in population in Canada: Data suggest that an SNP in the promoter region of ARPC3 (CpG-SNP rs3759384 C>T) is associated with metabolic syndrome complicated by severe abdominal obesity and hypertriglyceridemia in the population studied. PMID: 27055012
  3. Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells. PMID: 21251247
  4. The actin-related protein 3 structures were more visible with anti-p34Arc monoclonal antibody. PMID: 15793564
Subcellular Location
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein Families
ARPC3 family
Database Links

HGNC: 706

OMIM: 604225

KEGG: hsa:10094

STRING: 9606.ENSP00000228825

UniGene: Hs.524741

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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