ASAP3 Antibody

1. Results show that ASAP3 was amplified in colorectal cancer (CRC) tissues, and its upregulation was associated with poor prognosis of patients with CRC. Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO. These results suggest that ASAP3 acts as an oncogene. PMID: 28502111
2. The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility PMID: 24284654
3. ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion. PMID: 24078447
4. Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling. PMID: 23776207
5. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration PMID: 22027826
6. The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface. PMID: 20510928
7. ACAP4 is involved in ARF6-mediated cell migration. PMID: 16737952
8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion. PMID: 18400762

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HGNC: 14987

OMIM: 616594

KEGG: hsa:55616

STRING: 9606.ENSP00000338769

UniGene: Hs.437379