ATF6B Antibody

Code CSB-PA275866
Size US$297
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  • Western blot analysis of extracts from COLO205 cells, using ATF6B antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ATF6B Polyclonal antibody
Uniprot No.
Target Names
ATF6B
Alternative Names
ATF6B antibody; CREBL1 antibody; G13Cyclic AMP-dependent transcription factor ATF-6 beta antibody; cAMP-dependent transcription factor ATF-6 beta antibody; Activating transcription factor 6 beta antibody; ATF6-beta antibody; Protein G13 antibody; cAMP response element-binding protein-related protein antibody; Creb-rp antibody; cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human ATF6B.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR).; Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
Gene References into Functions
  1. ATF4 and ATF6beta act synergistically in the negative regulation of placental growth factor mRNA expression PMID: 26648175
  2. unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha PMID: 19693772
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus.
Protein Families
BZIP family, ATF subfamily
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 2349

OMIM: 600984

KEGG: hsa:1388

STRING: 9606.ENSP00000364349

UniGene: Hs.42853

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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