BECN1 Antibody

Datasheet
Code CSB-PA055976
Product Type Polyclonal Antibody
Size US$297
Uniprot No. Q14457
Image
  • Western blot analysis of extracts from Raji and K562 cells using Beclin-1 Antibody.
Immunogen Peptide sequence around aa.69-73( F-I-E-T-P) derived from Human Beclin-1.
Raised in Rabbit
Species Reactivity Human
Specificity The antibody detects endogenous level of total Beclin-1 protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.Nat. Cell Biol. 12:362-371(2010)
Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q.Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008)
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias ATG6; VPS30;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names BECN1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays a central role in autophagy
Subcellular Location Cytoplasm, Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Endosome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein, Mitochondrion membrane, Peripheral membrane protein, Endosome, Cytoplasmic vesicle, autophagosome
Protein Families Beclin family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 1034

OMIM: 604378

KEGG: hsa:8678

STRING: 9606.ENSP00000355231

UniGene: Hs.716464

Pathway Autophagy
Apelin signaling pathway

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