CALD1 Antibody

1. rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes. PMID: 28255976
2. ANXA1 and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression. PMID: 26657294
3. Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells. PMID: 26430961
4. Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. PMID: 24551305
5. caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum PMID: 23196794
6. The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD. PMID: 23418348
7. Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis. PMID: 23575144
8. Caldesmon expression inhibits cancer cell migration and invasiveness. PMID: 23265641
9. Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves PMID: 22316291
10. Data found phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium. PMID: 21738699
11. Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases. PMID: 21626272
12. Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers. PMID: 21184254
13. An involvement of caldesmon in the susceptibility to diabetic nephropathy in type 1 diabetes, independently from environmental glucose levels. PMID: 20801058
14. h-caldesmon is useful in distinguishing atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma PMID: 21131830
15. Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling PMID: 19834610
16. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
17. The effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin, was studied. PMID: 19889635
18. Specific but variable expression of h-caldesmon in leiomyosarcomas PMID: 11759055
19. Motifs of the caldesmon family. PMID: 11996092
20. results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes PMID: 15047636
21. Alternative splicing contributes to dysfunctionality of glioma neovascularization. PMID: 15161654
22. plays a crucial role in mediating the effects of Ca(2+)-calmodulin on the dynamics of the actin cytoskeleton PMID: 15226374
23. unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells PMID: 15456752
24. These results suggest that CaD is critically involved in the regulation of the actin cytoskeleton and migration in EC, and that p38 MAPK-mediated CaD phosphorylation may be involved in endothelial cytoskeletal remodeling. PMID: 15521070
25. Serum l-CaD level as determined by ELISA is a good discriminator between glioma patients versus patients with other intracranial tumor. PMID: 15958622
26. K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells PMID: 16115893
27. Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. PMID: 16800003
28. low molecular weight isoform CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature PMID: 17582218
29. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. PMID: 17631293
30. A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three organs and may represent general cancer-related splicing events. PMID: 18353764
31. GR directly bound to the two glucocorticoid-response element-like sequences in the human CALD1 promoter and transactivated the CALD1 gene, thereby up-regulating the CaD protein. PMID: 18772142
32. Vaginal caldesmon expression is significantly decreased in women with anterior vaginal wall prolapse compared to normal subjects PMID: 19582387

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HGNC: 1441

OMIM: 114213

KEGG: hsa:800

STRING: 9606.ENSP00000354826

UniGene: Hs.490203