CAMK2B Antibody

1. TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1. PMID: 28130256
2. Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control. PMID: 25045698
3. beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells PMID: 22750393
4. Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines. PMID: 21871176
5. Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible. PMID: 21884935
6. The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. PMID: 21479273
7. Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees PMID: 11710563
8. CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells PMID: 12496285
9. exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans PMID: 14565989
10. presence of a CaMKIIbeta isoform that can target the SR presumably via its membrane anchor alphaKAP defines a previously unrecognized Ca2+/CaM regulatory system in myocardium PMID: 15792370
11. thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II PMID: 16126727
12. expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases PMID: 16247765
13. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
14. These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo. PMID: 18302935
15. The expression of CaMKII beta was significantly elevated in schizophrenia and in depression. PMID: 16247765
16. mRNA levels are elevated in the frontal cortex in schizophrenia. PMID: 11042361

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HGNC: 1461

OMIM: 607707

KEGG: hsa:816

STRING: 9606.ENSP00000379098

UniGene: Hs.351887