anti-Homo sapiens (Human) Phospho-CAMK2B/CAMK2G/CAMK2D (Thr287) Antibody raised in Rabbit

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CAMK2B/CAMK2G/CAMK2D Polyclonal antibody

Uniprot No.

Target Names

CAMK2B/CAMK2G/CAMK2D

Alternative Names

Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody; Calcium/calmodulin dependent protein kinase II beta antibody; Calcium/calmodulin dependent protein kinase IIB antibody; Calcium/calmodulin dependent protein kinase type II beta chain antibody; calcium/calmodulin-dependent protein kinase II beta antibody; Calcium/calmodulin-dependent protein kinase type II subunit beta antibody; CAM 2 antibody; CaM kinase II beta chain antibody; CaM kinase II beta subunit antibody; CaM kinase II subunit beta antibody; CaM-kinase II beta chain antibody; CAM2 antibody; CAMK 2 antibody; CAMK 2B antibody; CaMK II beta subunit antibody; CaMK II subunit beta antibody; CaMK-II subunit beta antibody; CAMK2 antibody; CaMK2 beta antibody; Camk2b antibody; CAMKB antibody; CaMKII beta subunit antibody; CaMKIIB antibody; KCC2B_HUMAN antibody; MGC29528 antibody; Proline rich calmodulin dependent protein kinase antibody; proline rich calmodulin-dependent protein kinase antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Peptide sequence around phosphorylation site of Threonine 287(Q-E-T(p)-V-E) derived from Human CaMK2- beta/ gamma/ delta.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Gene References into Functions	TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1. PMID: 28130256 Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control. PMID: 25045698 beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells PMID: 22750393 Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines. PMID: 21871176 Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible. PMID: 21884935 The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. PMID: 21479273 Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees PMID: 11710563 CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells PMID: 12496285 exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans PMID: 14565989 presence of a CaMKIIbeta isoform that can target the SR presumably via its membrane anchor alphaKAP defines a previously unrecognized Ca2+/CaM regulatory system in myocardium PMID: 15792370 thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II PMID: 16126727 expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases PMID: 16247765 regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996 These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo. PMID: 18302935 The expression of CaMKII beta was significantly elevated in schizophrenia and in depression. PMID: 16247765 mRNA levels are elevated in the frontal cortex in schizophrenia. PMID: 11042361 Show More Hide All
Subcellular Location	Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Sarcoplasmic reticulum membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Tissue Specificity	Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
Database Links	HGNC: 1461 OMIM: 607707 KEGG: hsa:816 STRING: 9606.ENSP00000379098 UniGene: Hs.351887

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Check Code：

Code	CSB-PA283993
Size	US$360
Image	Western blot analysis of extracts from Rat brain using CaMK2- beta/ gamma/ delta (Phospho-Thr287) Antibody.The lane on the right is treated with the antigen-specific peptide.
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Phospho-CAMK2B/CAMK2G/CAMK2D (Thr287) Antibody

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Target Data

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