CASP9 Antibody

Datasheet
Code CSB-PA828671
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P55211
Image
  • Western blot analysis of extracts from 293 and Hela cells using Caspase 9 Antibody.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9
Raised in Rabbit
Species Reactivity Human
Specificity The antibody detects endogenous level of total Caspase 9 protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556.
Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.
Li, P. et al. (1997) Cell 91, 479-489.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias ICE-like apoptotic protease 6
Immunogen Species Homo sapiens (Human)
Target Names CASP9
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION
Protein Families Peptidase C14A family
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Database Links

HGNC: 1511

OMIM: 602234

KEGG: hsa:842

STRING: 9606.ENSP00000330237

UniGene: Hs.329502

Pathway p53 signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Apoptosis

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