CASP9

CASP9, also known as caspase 9, is a cysteine-aspartic protease that plays a crucial role in the intrinsic apoptosis pathway. It is activated in the apoptosome complex, where it cleaves downstream effector caspases to induce apoptosis. CASP9 is involved in various signaling pathways, including the mitochondria-mediated pathway, and is associated with numerous diseases such as neurodegenerative disorders, cancer, and cardiovascular diseases. Research on CASP9 has led to the development of potential therapeutic targets, including inhibitors and dominant-negative mutants, for treating these diseases.