CBLC Antibody

Datasheet

Code	CSB-PA892346ESR2HU
Size	US$166
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Image	Western blot All lanes: CBLC antibody at 14µg/ml Lane 1: A549 whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 53, 48 kDa Observed band size: 53 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA892346ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA892346ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CBLC Polyclonal antibody

Uniprot No.

Q9ULV8

Target Names

CBLC

Alternative Names

CBLC antibody; CBL3 antibody; RNF57E3 ubiquitin-protein ligase CBL-C antibody; EC 2.3.2.27 antibody; RING finger protein 57 antibody; RING-type E3 ubiquitin transferase CBL-C antibody; SH3-binding protein CBL-3 antibody; SH3-binding protein CBL-C antibody; Signal transduction protein CBL-C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Gene References into Functions

Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype PMID: 28481040
Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus. PMID: 26393512
Silencing of CBLC causes increased sensitivity to PARP1 inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause. PMID: 25883215
the effects of two pathogenic missense mutations on the the catalytic activities of the human B12-processing chaperone CblC PMID: 25809485
This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients PMID: 24599607
The ubiquitin ligase activity of Cbl-c by the direct interaction of the LIM zinc coordinating domain of Hic5 is demonstrated. PMID: 23145173
the N terminus of Cbl-c contributes to the binding to the E2 and phosphorylation of Tyr-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl-c PMID: 20525694
Data demonstrate that two E3 ligases of different classes, CBLC and AIP4, can interact and cooperate to down-regulate EGFR signaling. PMID: 12226085
c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis. PMID: 12244174
Src is a preferential target of Cbl-c for degradation PMID: 14661060
ubiquitin protein ligase activity is regulated in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations PMID: 15117950

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Tissue Specificity

Ubiquitous.

Database Links

HGNC: 15961

OMIM: 608453

KEGG: hsa:23624

STRING: 9606.ENSP00000270279

UniGene: Hs.466907

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

ErbB signaling pathway Ubiquitin mediated proteolysis T cell receptor signaling pathway Insulin signaling pathway Endocytosis Melanogenesis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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