CD209

CD209, also known as DC-SIGN (Dendritic Cell-Specific ICAM3-grabbing Non-integrin), is a C-type lectin receptor expressed on the surface of dendritic cells and macrophages. It plays a crucial role in immune responses by binding to pathogens and facilitating their uptake and presentation to T cells. CD209 is involved in various signaling pathways, including those related to viral infections and inflammation. It is associated with diseases such as dengue fever, HIV, and tick-borne encephalitis. Research on CD209 has led to potential therapeutic targets for antiviral drug development, particularly in the context of COVID-19, where CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 entry into human cells.