CD72 Antibody

Code CSB-PA004955LA01HU
Size US$299 How to order?
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
    All lanes: CD72 antibody at 3.2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41 kDa
    Observed band size: 41 kDa

  • Immunofluorescence staining of Hela cells with CSB-PA004955LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CD72 Polyclonal antibody
Uniprot No. P21854
Target Names CD72
Alternative Names CD72; B-cell differentiation antigen CD72; Lyb-2; CD antigen CD72
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human B-cell differentiation antigen CD72 protein (150-208AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The CD72 Antibody (Product code: CSB-PA004955LA01HU) is Non-conjugated. For CD72 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004955LB01HU CD72 Antibody, HRP conjugated ELISA
FITC CSB-PA004955LC01HU CD72 Antibody, FITC conjugated
Biotin CSB-PA004955LD01HU CD72 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in B-cell proliferation and differentiation.
Gene References into Functions
  1. Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction. PMID: 28222623
  2. Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis PMID: 26883681
  3. CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals. PMID: 24461079
  4. data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis PMID: 23184497
  5. regulates serum immunoglobulin leveln and disease resistance in systemic lupus erythematosus PMID: 23268649
  6. CD72 mRNA expression level correlates with Sema4D expression in peripheral blood mononuclear cells in immune thrombocytopenia. PMID: 22111667
  7. CD100, CD72 and CD45 were expressed in placenta and exhibited different mRNA and protein levels in normal pregnancy and miscarriage. Protein levels were highly dysregulated around 10 weeks of gestation in first and second miscarriage placentas. PMID: 22606231
  8. CD100-CD72 interaction can be the mechanism by which NK cell communicate with B cells. PMID: 17786190
  9. Data show that ligation of CD72 with the BU40, or with rCD100 negatively regulates KIT-mediated mast cell proliferation, chemotaxis, and chemokine production. PMID: 20100931
  10. results indicated that the presence of CD72-*2 allele decreases risk for human systemic lupus erythematosus conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72 PMID: 15459183
  11. CD72 is a key molecule in regulating mature B cell differentiation; CD72 signaling reduces the expression of X-box binding protein 1 in B cells PMID: 16047337
  12. increased nucleotide mutation of CD72 mRNA accounts for the decreased expression level of CD72 in B cells, and it might be related to hyperactivity of B cells in patients with SLE PMID: 17121583
  13. CD72 polymorphisms are associated with age of appearing clinical manifestations in idiopathic thrombocytopenic purpura in Chinese patients. PMID: 18071878

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Subcellular Location Membrane; Single-pass type II membrane protein.
Tissue Specificity Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Database Links

HGNC: 1696

OMIM: 107272

KEGG: hsa:971

STRING: 9606.ENSP00000259633

UniGene: Hs.116481

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