CD72

CD72, also known as Lyb-2, is a single-pass Type-II membrane protein with an extracellular C-type lectin domain and cytoplasmic ITIM motifs. It serves as an inhibitor of B-cell receptor signaling by recruiting phosphatase SHP-1 to the ITIM motifs. CD72 is highly expressed in B-cell malignancies, including acute lymphoblastic leukemia and diffuse large B-cell lymphoma, and is associated with poor prognosis. It is also involved in immune regulation, and its expression is regulated by B-cell-related transcription factors. CD72 has emerged as a potential target for immunotherapy, with ongoing research focusing on CAR-T cell development and combination strategies with other therapies.

CD72 is a promising therapeutic target in B-cell malignancies due to its role in BCR signaling and its expression in various B-cell cancers. Research into CD72-directed CAR-T cells and combination therapies with SHIP1 inhibition is ongoing, aiming to improve treatment outcomes for patients with CD72-positive B-cell malignancies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD72 Antibody (CSB-PA004955LA01HU)

Validated Data

Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
All lanes: CD72 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa

Immunofluorescence staining of Hela cells with CSB-PA004955LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human B-cell differentiation antigen CD72(CD72) ELISA kit (CSB-EL004955HU)

Validated Data

Code: CSB-EL004955HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.225 ng/mL

Detection Range: 0.9 ng/mL-60 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CD72 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CD72 Antibodies

CD72 Proteins

CD72 ELISA Kits

CD72 Antibodies

CD72 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA004955GA01HU	CD72 Antibody	Human	ELISA,WB
CSB-PA215043	CD72 Antibody	Human	WB, ELISA
CSB-PA004955LA01HU	CD72 Antibody	Human	ELISA, WB, IF

CD72 Proteins

CD72 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF004955MO	Recombinant Mouse B-cell differentiation antigen CD72 (Cd72)	in vitro E.coli expression system
CSB-YP004955MO1 CSB-EP004955MO1 CSB-BP004955MO1 CSB-EP004955MO1-B	Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

CD72 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF004955HU	Recombinant Human B-cell differentiation antigen CD72 (CD72)	in vitro E.coli expression system
CSB-YP004955HU1 CSB-EP004955HU1 CSB-BP004955HU1 CSB-EP004955HU1-B	Recombinant Human B-cell differentiation antigen CD72 (CD72), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP004955HU1	Recombinant Human B-cell differentiation antigen CD72 (CD72), partial	Mammalian cell

CD72 ELISA Kit

CD72 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL004955HU	Human B-cell differentiation antigen CD72(CD72) ELISA kit	serum, plasma, tissue homogenates	0.225 ng/mL

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CD72

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