CDH1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA06239D0Rb
Size US$299
Uniprot No. P12830
Immunogen Recombinant Human Cadherin-1 protein (153-641AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3], CDH1, CDHE UVO
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names CDH1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cadherins are calcium-dependent cell adhesion proteins
Involvement in disease Hereditary diffuse gastric cancer (HDGC); Endometrial cancer (ENDMC); Ovarian cancer (OC); Breast cancer, lobular (LBC); Blepharocheilodontic syndrome 1 (BCDS1)
Subcellular Location Cell junction, Cell membrane, Single-pass type I membrane protein, Endosome, Golgi apparatus, trans-Golgi network
Tissue Specificity Non-neural epithelial tissues.
Database Links

HGNC: 1748

OMIM: 119580

KEGG: hsa:999

STRING: 9606.ENSP00000261769

UniGene: Hs.461086

Pathway Hippo signaling pathway
Adherens junction
Apelin signaling pathway
Rap1 signaling pathway

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