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The CDH1 recombinant monoclonal antibody is produced on the basis of recombinant DNA technology and can detect human CDH1 protein in ELISA and IHC applications. To create the antibody, the gene that codes for the CDH1 monoclonal antibody is synthesized by sequencing the cDNA of CDH1 antibody-producing hybridomas. These hybridomas are generated by fusing B cells from animals immunized with a synthesized peptide derived from human CDH1 with myeloma cells. The synthesized gene is then cloned into a vector and transfected into cells for cultivation. Finally, the resulting CDH1 recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
The CDH1 protein, also known as E-cadherin, is a calcium-dependent cell adhesion molecule that plays a critical role in maintaining cell-cell adhesion and tissue integrity. CDH1 is primarily expressed in epithelial tissues, where it mediates the formation of adherens junctions (AJs) between adjacent cells. CDH1 has been implicated in the regulation of various cellular processes, including cell proliferation, differentiation, migration, and apoptosis. Dysregulation of CDH1 expression or function has been associated with various diseases, including cancer and developmental disorders.
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