CPA1 Antibody

Code CSB-PA001768
Size US$167
Image
  • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
  • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
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Product Details

Uniprot No. P15085
Target Names CPA1
Alternative Names carboxypeptidase A1 (pancreatic) antibody; Carboxypeptidase A1 antibody; Carboxypeptidase A1 precursor antibody; CBPA1_HUMAN antibody; CPA antibody; CPA1 antibody; Pancreatic carboxypeptidase A1 antibody; Procarboxypeptidase A1 pancreatic antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the Internal region of Human CPA1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Gene References into Functions
  1. study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. PMID: 29669919
  2. Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort PMID: 28497564
  3. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
  4. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. PMID: 27358403
  5. mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity PMID: 23955596
  6. Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy PMID: 21502183
  7. A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract. PMID: 18566513

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Subcellular Location Secreted
Protein Families Peptidase M14 family
Database Links

HGNC: 2296

OMIM: 114850

KEGG: hsa:1357

STRING: 9606.ENSP00000011292

UniGene: Hs.2879

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