CPN1 Antibody

Code CSB-PA447827
Size US$297
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  • Western blot analysis of extracts from RAW264.7 cells, using CPN1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CPN1 Polyclonal antibody
Uniprot No.
Target Names
CPN1
Alternative Names
ACBP antibody; Anaphylatoxin inactivator antibody; Arginine carboxypeptidase antibody; Carboxypeptidase N catalytic chain antibody; Carboxypeptidase N polypeptide 1 50 kD antibody; Carboxypeptidase N polypeptide 1 antibody; Carboxypeptidase N small subunit antibody; Carboxypeptidase N subunit 1 antibody; CBPN_HUMAN antibody; CPN antibody; CPN1 antibody; Kininase 1 antibody; Kininase-1 antibody; Kininase1 antibody; Lysine carboxypeptidase antibody; Plasma carboxypeptidase B antibody; SCPN antibody; Serum carboxypeptidase N antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from C-terminal of Human CPN1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Gene References into Functions
  1. CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma. PMID: 23000409
  2. carboxypeptidase N regulates the biologic activity of SDF-1alpha by reducing the chemokine-specific activity PMID: 15718415
  3. This review summarizes the structure, enzymatic properties and function of this enzyme, including insights gained by the recent elucidation of the crystal structure of the CPN catalytic subunit and structural modeling of the non-catalytic 83 kDa subunit. PMID: 18039526
Involvement in disease
Carboxypeptidase N deficiency (CPND)
Subcellular Location
Secreted, extracellular space.
Protein Families
Peptidase M14 family
Tissue Specificity
Synthesized in the liver and secreted in plasma.
Database Links

HGNC: 2312

OMIM: 212070

KEGG: hsa:1369

STRING: 9606.ENSP00000359446

UniGene: Hs.2246

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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