CR1 Antibody

Datasheet
Code CSB-PA065723
Size US$299
Uniprot No. P17927
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA065723(CR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA065723(CR1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthetic peptide of Human CR1
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:25-1:100
Relevance This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias complement component (3b/4b) receptor 1 (Knops blood group)
Immunogen Species Homo sapiens (Human)
Target Names CR1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Mediates cellular binding of particles and immune complexes that have activated complement.; FUNCTION
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Receptors of complement activation (RCA) family
Tissue Specificity Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Database Links

HGNC: 2334

OMIM: 120620

KEGG: hsa:1378

STRING: 9606.ENSP00000356016

UniGene: Hs.334019

Pathway Complement and coagulation cascades
Hematopoietic cell lineage

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