CREB3L2 Antibody

Datasheet

Code	CSB-PA754617ESR2HU
Size	US$166
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Image	Western blot All lanes: CREB3L2 antibody at 6μg/ml Lane 1: Mouse liver tissue Lane 2: Mouse lung tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 58, 51, 28 kDa Observed band size: 58 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA754617ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA754617ESR2HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA754617ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CREB3L2 Polyclonal antibody

Uniprot No.

Q70SY1

Target Names

CREB3L2

Alternative Names

B ZIB transcription factor antibody; Basic transcription factor 2 antibody; BBF2 human homolog on chromosome 7 antibody; BBF2H7 antibody; BZIB transcription factor antibody; cAMP responsive element binding protein 3 like 2 antibody; cAMP-responsive element-binding protein 3-like protein 2 antibody; CR3L2_HUMAN antibody; Creb3l2 antibody; Cyclic AMP-responsive element-binding protein 3-like protein 2 antibody; FUS/BBF2H7 protein antibody; MGC131709 antibody; MGC71006 antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 2 antibody; TCAG_1951439 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2 protein (1-247AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.

Gene References into Functions

UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. PMID: 28500182
These data suggest that the secreted luminal BBF2H7 C-terminus is involved in Hedgehog ligand-dependent cancer cell proliferation through activation of Hedgehog signaling. BBF2H7 C-terminus may be a novel target for the development of anticancer drugs. PMID: 25955804
the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis PMID: 22495181
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. PMID: 21536545
We characterized a widely expressed transcript of CREB3L2 generated by an intronic polyadenylation site in intron 4 of the gene. PMID: 20878102
The human Creb3L2 can activate SPCG transcription in a heterologous system(Drosophila embryos), which suggests a general and direct role for this family of bZip transcription factors in mediating high-level secretory capacity. PMID: 21041443
Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome is associated with low-grade fibromyxoid sarcoma. PMID: 20471519
BBF2H7 was fused with FUS in a low grade myxoid liposarcoma. PMID: 12915480
CREB3L2 is not only structurally, but also functionally very similar to CREB3L1. PMID: 17117415
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulumm stress transducer. PMID: 17178827
Presence of FUS/CREB3L2 and FUS/CREB3L1 in low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma suggests these neoplasms may be related. PMID: 17721195
findings identify a novel CREB3L2-PPARgamma gene fusion mutation in thyroid carcinoma and reveal a thyroid signaling pathway that is regulated by intramembrane proteolysis and disrupted in cancer PMID: 18757431
We characterized the promoter region of CREB3L2, showing that it is asymmetrically bidirectional PMID: 19212619

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Involvement in disease

A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.

Database Links

HGNC: 23720

OMIM: 608834

KEGG: hsa:64764

STRING: 9606.ENSP00000329140

UniGene: Hs.490273

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

cAMP signaling pathway Estrogen signaling pathway Melanogenesis PI3K-Akt signaling pathway TNF signaling pathway Th17 cell differentiation Thyroid hormone synthesis AMPK signaling cGMP-PKG signaling pathway Glucagon signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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