CREB3L3 Antibody

1. CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. PMID: 29738435
2. Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H. PMID: 27029215
3. Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance. PMID: 26427795
4. CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID: 25428452
5. Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis PMID: 23957007
6. Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia. PMID: 22262056
7. a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH PMID: 21693703
8. Levels of CREB transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues. PMID: 12039695
9. analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis PMID: 17875199
10. findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin promoter PMID: 19679815

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HGNC: 18855

OMIM: 611998

KEGG: hsa:84699

STRING: 9606.ENSP00000078445

UniGene: Hs.247744