CREB3L4 Antibody

Datasheet

Code	CSB-PA844735LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA844735LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CREB3L4 Polyclonal antibody

Uniprot No.

Q8TEY5

Target Names

CREB3L4

Alternative Names

1700012K17Rik antibody; AIbZIP antibody; Androgen induced basic leucine zipper antibody; Androgen induced basic leucine zipper protein antibody; Androgen-induced basic leucine zipper protein antibody; ATCE1 antibody; Attaching to CRE like 1 antibody; Attaching to CRE-like 1 antibody; cAMP responsive element binding protein 1 antibody; cAMP responsive element binding protein 3 like 4 antibody; cAMP responsive element binding protein 4 antibody; cAMP responsive element-binding protein 3 like protein 4 antibody; cAMP-responsive element-binding protein 3-like protein 4 antibody; cAMP-responsive element-binding protein 4 antibody; CR3L4_HUMAN antibody; CREB 4 antibody; CREB-4 antibody; CREB3 antibody; CREB3L4 antibody; CREB4 antibody; Cyclic AMP responsive element binding protein 3 like protein 4 antibody; Cyclic AMP responsive element binding protein 4 antibody; Cyclic AMP-responsive element-binding protein 4 antibody; hJAL antibody; JAL antibody; mJAL antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody; Tisp40 antibody; Tisp40alpha antibody; Tisp40beta antibody; Transcript induced in spermiogenesis protein 40 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 4 protein (13-133AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CREB3L4 Antibody (Product code: CSB-PA844735LA01HU) is Non-conjugated. For CREB3L4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA844735LB01HU	CREB3L4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA844735LC01HU	CREB3L4 Antibody, FITC conjugated
Biotin	CSB-PA844735LD01HU	CREB3L4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.

Gene References into Functions

CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding. PMID: 28338058
AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells. PMID: 27853318
AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. PMID: 11830526
identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues PMID: 12111373
S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region PMID: 16236796
In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis. PMID: 17712038

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than

Database Links

HGNC: 18854

OMIM: 607138

KEGG: hsa:148327

STRING: 9606.ENSP00000271889

UniGene: Hs.372924

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

cAMP signaling pathway Estrogen signaling pathway Melanogenesis PI3K-Akt signaling pathway TNF signaling pathway Th17 cell differentiation AMPK signaling cGMP-PKG signaling pathway Glucagon signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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