CSNK1E Antibody

Code CSB-PA907561
Size US$297
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Image
  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using CKI-ε antibody.
  • Immunofluorescence analysis of HeLa cells, using CKI-ε antibody.
  • Western blot analysis of extracts from LOVO cells, using CKI-ε antibody.
  • Western blot analysis of extracts from HuvEc cells (Lane 2), JK cells (Lane 3) and cos-7 cells (Lane 4), using CKI-ε antiobdy antiobdy. The lane on the left is treated with synthesized peptide.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CSNK1E Polyclonal antibody
Uniprot No.
Target Names
CSNK1E
Alternative Names
Casein kinase 1 epsilon antibody; Casein kinase I antibody; Casein kinase I epsilon antibody; Casein kinase I isoform epsilon antibody; CKI epsilon antibody; CKI-epsilon antibody; CKIe antibody; CKIepsilon antibody; CSNK 1E antibody; CSNK1E antibody; DBT antibody; Doubletime, Drosophila, homolog of antibody; EC 2.7.11.1 antibody; epsilon isoform antibody; HCK IE antibody; KC1E antibody; KC1E_HUMAN antibody; kinase CK1 epsilon antibody; MGC 10398 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human CKI-ε.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Gene References into Functions
  1. CKI-epsilon is a potent TDP-43 kinase in vivo and in vitro. PMID: 24105464
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Tissue Specificity
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Database Links

HGNC: 2453

OMIM: 600863

KEGG: hsa:102800317

STRING: 9606.ENSP00000352929

UniGene: Hs.474833

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