CTNND1 Antibody

Code CSB-PA003612
Size US$167Purchase it in Cusabio online store
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  • Western Blot analysis of HuvEc cells using p120 Polyclonal Antibody
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Product Details

Uniprot No. O60716
Target Names CTNND1
Alternative Names Cadherin associated Src substrate antibody; Cadherin-associated Src substrate antibody; CAS antibody; Catenin (cadherin associated protein) delta 1 antibody; Catenin delta 1 antibody; Catenin delta antibody; Catenin delta-1 antibody; CTND1_HUMAN antibody; CTNND 1 antibody; CTNND antibody; CTNND1 antibody; delta 1 Catenin antibody; KIAA0384 antibody; p120 antibody; P120 CAS antibody; p120 catenin antibody; P120 CTN antibody; p120(cas) antibody; p120(ctn) antibody; P120CAS antibody; P120CTN antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from Human p120 around the non-phosphorylation site of Y228.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Gene References into Functions
  1. pathogenic variants are described in four genes encoding components of the p120-catenin complex (CTNND1, PLEKHA7, PLEKHA5) and an epithelial splicing regulator (ESRP2), in addition to the known Cleft lip/Palate-associated gene, CDH1, which encodes E-cadherin. PMID: 29805042
  2. CTNND1 binds to CDH1 and controls the stability of the complex. PMID: 29348693
  3. miR-298 suppresses hepatocellular carcinoma progression at least partially by targeting CTNND1-mediated Wnt/beta-catenin signaling. PMID: 29990836
  4. these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration. PMID: 30249887
  5. Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. PMID: 28004812
  6. Results provide evidence that 90K interacts with the E-cadherin-p120-catenin complex and induced its dissociation, altering the phosphorylation status of p120-catenin. PMID: 29207493
  7. Results show that head and neck squamous cell carcinoma tumors with low P120CTN and PI3K pathway mutations have higher levels of MMP1 compared to tumors with high P120CTN and no PI3K pathway mutations demonstrating that P120CTN downregulation and PIK3CA mutations promote MMP1-driven invasion. PMID: 28637905
  8. In 11 BCD patients from eight families, we identified five CDH1 deleterious missense mutations and three CTNND1 truncating mutations. PMID: 28301459
  9. Our combined data indicate that as HPMECs achieve confluence and CD31 ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31, permitting NEU1-mediated desialylation of CD31. PMID: 28343945
  10. Studied interactions between protein kinase C alpha (PKCalpha), FOXC2, and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer PMID: 29216867
  11. Studied the association between genetic polymorphisms in the CTNND1 gene and risk of pancreatic carcinoma in Chinese population. PMID: 27565611
  12. Results found that CTNND1 expression was significantly up-regulated in hepatocellular carcinoma (HCC) cancer lesions compared with paired normal liver tissues and, could promote cell proliferation, migration, and invasion in vitro and in vivo. The study provides evidence that CTNND1 functions as a novel tumor oncogene in HCC. PMID: 27193094
  13. These results suggest that stabilization of delta-catenin by Hakai is dependent on Src. PMID: 28069439
  14. These results uncover a new role for p120 catenin bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface. PMID: 27254316
  15. recent results describing actions of p120-catenin in different phases of this pathway PMID: 28276699
  16. The mTOR-dependent, epithelial phenotype of TSC astrocytes suggests TSC1/2 and mTOR tune the phosphorylation level of catenin delta-1 by controlling PKCe activity, thereby regulating the mesenchymal-epithelial-transition (MET) PMID: 27516388
  17. Src-dependent phosphorylation of p120(ctn) can respond rapidly to negative pressure and contribute to E-cadherin downregulation. PMID: 27220534
  18. p120 participates in the progress of gastric cancer through regulating Rac1 and Pak1. PMID: 26324182
  19. The overexpression of P120ctn led to a decrease in both invasion and migration capacity of HN12 cells accompanied by a decrease in EMT markers. Knockdown of P120ctn led to an increase in both invasion and migration capacity accompanied by an increase in EMT markers. PMID: 27146732
  20. OGT inhibited the formation of the Ecadherin/catenin complex through reducing the interaction between p120 and Ecadherin. PMID: 26707622
  21. Immunohistochemical panel of CDX2, p120ctn, c-Myc, and Jagged1 proteins would be to distinguish between low/high grade dysplasia in histologically challenging cases of Barrett's esophagus. PMID: 26926447
  22. p120ctn improves the BBB dysfunction and inflammatory responses induced by LPS through the inhibition of NF-kappaB activation. PMID: 26097613
  23. expression of catenin-delta1 rescued the inhibitory effect of miR-409-3p on cell migration and invasion PMID: 26992637
  24. expression of E-cadherin, and p120 negatively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
  25. Survival time of colorectal cancer patients with positive deltacatenin expression was shorter than that of patients with negative deltacatenin expression. PMID: 26062780
  26. results indicate an anti-inflammatory effect of p120 in bronchial epithelial cells through its modulation of NF-kappaB signaling depending on RhoA/ROCK pathway. PMID: 25693631
  27. Phosphorylation and isoform use in p120-catenin during development and tumorigenesis. PMID: 26477567
  28. PLEKHA7 localization to adherens junctions is E-cadherin and p120 dependent. PMID: 26302406
  29. Pro-Tumorigenic Phosphorylation of p120 Catenin is associated with Renal and Breast Cancer. PMID: 26067913
  30. the modulation of HPV-16 E6/E7 expression remarkably influenced cell proliferation, migration, and invasion, as well as the protein levels of E-cadherin and P-cadherin in cervical cell lines. PMID: 26093522
  31. The expression, redistribution and disassociation of junction proteins in ventilator-induced lung injury were all restored with p120-catenin overexpression. PMID: 25986488
  32. localization of p120 catenin in the cytoplasm rather than the membrane correlates with poor prognosis in esophageal squamous cell carcinoma PMID: 25785604
  33. Enforced expression of miR-29s in gastric cancer cells inhibited cell invasion in vitro and in vivo by directly targeting CTNND1. PMID: 25634213
  34. C6orf106 promotes invasion in NSCLC cells. Finally, C6orf106 upregulates vimentin, and downregulates E-cadherin and P120ctn. PMID: 25736925
  35. p120ctn down-regulation and EGFR overexpression are able to mimic human ESCC in a culture model PMID: 25529795
  36. MiR-145 inhibits invasion of gastric cancer cells not only by down-regulating cytoplasmic catenin-delta1 expression but also by inducing the translocation of catenin-delta1 PMID: 25470111
  37. We conclude that delta-catenin tends to overexpress in breast carcinoma and promotes the malignant phenotype PMID: 25273174
  38. uncovering a critical role for CTNND2 in neuronal development and an intimate connection to chromatin biology; data contribute to the understanding of the genetic architecture of autism PMID: 25807484
  39. our study supports the regulatory role of p120 in airway inflammation and reveals that p120 may modulate NF-kappaB signaling partially through RhoA. PMID: 24995336
  40. E-cadherin and P120 catenin cocktail immunostain can be used to differentiate ductal carcinoma in situ from lobular carcinoma in situ. PMID: 24966968
  41. Overexpression of delta-catenin reduces the expression of E-cadherin and alters the balance between E-cadherin and p120ctn, which in turn affects the formation of intercellular adhesions and promotes invasion and metastasis in Colorectal cancer. PMID: 23423910
  42. Transfection of in H1299 cells expressing low p120ctn levels. PMID: 24505377
  43. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 and its availability to control Rho GTPase activity PMID: 24284071
  44. P120ctn plays a pivotal role in the proliferation. PMID: 23073801
  45. Overexpression of HO-1 promotes Caco-2 cell proliferation and migration by targeting the CTNND1 gene. PMID: 23981612
  46. P120 catenin ARM domains 1, 3-5, and 8 mediate interactions between p120 catenin and MUC1. PMID: 24371222
  47. The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling. PMID: 24474278
  48. these results indicate that c-Src can enhance the oncogenic function of delta-catenin in prostate cancer cells PMID: 24412473
  49. Overexpression of NLBP promotes the cell proliferation of lung adenocarcinoma through interacting with p120ctn. PMID: 23839039
  50. p120ctn delocalization/loss of expression could be an independent prognostic marker in oral squamous cell carcinoma PMID: 23706919

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Involvement in disease Blepharocheilodontic syndrome 2 (BCDS2)
Subcellular Location Cytoplasm, Nucleus, Cell membrane
Protein Families Beta-catenin family
Tissue Specificity Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and gener
Database Links

HGNC: 2515

OMIM: 601045

KEGG: hsa:1500

STRING: 9606.ENSP00000382004

UniGene: Hs.166011

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