CTPS1 Antibody

Code CSB-PA006176LA01HU
Size US$166
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  • Western blot
    All lanes: CTPS1 antibody at 6µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 67, 42 kDa
    Observed band size: 67 kDa

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA006176LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006176LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CTPS1 Polyclonal antibody
Uniprot No.
Target Names
CTPS1
Alternative Names
CTPS1 antibody; CTPS antibody; CTP synthase 1 antibody; EC 6.3.4.2 antibody; CTP synthetase 1 antibody; UTP--ammonia ligase 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human CTP synthase 1 protein (300-554AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CTPS1 Antibody (Product code: CSB-PA006176LA01HU) is Non-conjugated. For CTPS1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006176LB01HU CTPS1 Antibody, HRP conjugated ELISA
FITC CSB-PA006176LC01HU CTPS1 Antibody, FITC conjugated
Biotin CSB-PA006176LD01HU CTPS1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Gene References into Functions
  1. CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
  2. The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
  3. Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
  4. results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
  5. analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
  6. CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
  7. Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
  8. analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
  9. studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551

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Involvement in disease
Immunodeficiency 24 (IMD24)
Subcellular Location
Cytoplasm, cytosol.
Protein Families
CTP synthase family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 2519

OMIM: 123860

KEGG: hsa:1503

STRING: 9606.ENSP00000361699

UniGene: Hs.473087

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