Cleaved-CTSV (L114) Antibody

Code CSB-PA000037
Size US$167Purchase it in Cusabio online store
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  • Western Blot analysis of HeLa cells using Cleaved-Cathepsin L2 (L114) Polyclonal Antibody
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Product Details

Uniprot No. O60911
Target Names CTSV
Alternative Names CAT L2 antibody; Cathepsin L2 antibody; Cathepsin U antibody; Cathepsin V antibody; CathepsinL2 antibody; CathepsinU antibody; CathepsinV antibody; CATL 2 antibody; CATL2 antibody; CATL2_HUMAN antibody; CTS L2 antibody; CTS U antibody; CTS V antibody; CTSL 2 antibody; CTSL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; PRO305 antibody; UNQ268 antibody
Raised in Rabbit
Species Reactivity Human,Monkey
Immunogen Synthesized peptide derived from the Internal region of Human Cathepsin L2.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cysteine protease. May have an important role in corneal physiology.
Gene References into Functions
  1. CTSV is involved in melanosome degradation. PMID: 29654760
  2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
  3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
  4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
  5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
  6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
  7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
  8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
  9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
  10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
  11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
  12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
  13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
  14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
  15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
  16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
  17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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Subcellular Location Lysosome
Protein Families Peptidase C1 family
Tissue Specificity Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
Database Links

HGNC: 2538

OMIM: 603308

KEGG: hsa:1515

STRING: 9606.ENSP00000259470

UniGene: Hs.610096

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