CTSV Antibody

Datasheet

Code	CSB-PA006194ESR2HU
Size	US$166
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Image	Western blot All lanes: CTSV antibody at 12μg/ml Lane 1: Jurkat whole cell lysate Lane 2: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 37 kDa Observed band size: 37 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006194ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006194ESR2HU at dilution of 1:100
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CTSV Polyclonal antibody

Uniprot No.

O60911

Target Names

CTSV

Alternative Names

CAT L2 antibody; Cathepsin L2 antibody; Cathepsin U antibody; Cathepsin V antibody; CathepsinL2 antibody; CathepsinU antibody; CathepsinV antibody; CATL 2 antibody; CATL2 antibody; CATL2_HUMAN antibody; CTS L2 antibody; CTS U antibody; CTS V antibody; CTSL 2 antibody; CTSL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; PRO305 antibody; UNQ268 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cathepsin L2 protein (105-334AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

The clinicopathological significance of thymic epithelial markers expression in thymoma and thymic carcinoma H Li,BMC cancer,2023

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : Immunohistochemical staining

Sample type: cell

Review: For immunohistochemical analysis, the antibodies employed included PRSS16, cathepsin V, claudin-4, CD40. Expression of cortical epithelial markers in thymoma and TSCC.A network of PRSS16-positive epithelial cells was seen in B2.

By Anonymous

Target Background

Function

Cysteine protease. May have an important role in corneal physiology.

Gene References into Functions

CTSV is involved in melanosome degradation. PMID: 29654760
exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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Subcellular Location

Lysosome.

Protein Families

Peptidase C1 family

Tissue Specificity

Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.

Database Links

HGNC: 2538

OMIM: 603308

KEGG: hsa:1515

STRING: 9606.ENSP00000259470

UniGene: Hs.610096

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Apoptosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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