Recombinant Human Cathepsin L2 (CTSL2)

Code CSB-YP006194HU
MSDS
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Source Yeast
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Code CSB-EP006194HU
MSDS
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Source E.coli
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Code CSB-EP006194HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP006194HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP006194HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
CAT L2; Cathepsin L2; Cathepsin U; Cathepsin V; CathepsinL2; CathepsinU; CathepsinV; CATL 2; CATL2; CATL2_HUMAN; CTS L2; CTS U; CTS V; CTSL 2; CTSL2; CTSU; CTSV; MGC125957; PRO305; UNQ268
Species
Homo sapiens (Human)
Expression Region
114-334
Target Protein Sequence
LPKSVDW RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS RPQGNQGCNG GFMARAFQYV KENGGLDSEE SYPYVAVDEI CKYRPENSVA NDTGFTVVAP GKEKALMKAV ATVGPISVAM DAGHSSFQFY KSGIYFEPDC SSKNLDHGVL VVGYGFEGAN SNNSKYWLVK NSWGPEWGSN GYVKIAKDKN NHCGIATAAS YPNV
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cysteine protease. May have an important role in corneal physiology.
Gene References into Functions
  1. CTSV is involved in melanosome degradation. PMID: 29654760
  2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
  3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
  4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
  5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
  6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
  7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
  8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
  9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
  10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
  11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
  12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
  13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
  14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
  15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
  16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
  17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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Subcellular Location
Lysosome.
Protein Families
Peptidase C1 family
Tissue Specificity
Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
Database Links

HGNC: 2538

OMIM: 603308

KEGG: hsa:1515

STRING: 9606.ENSP00000259470

UniGene: Hs.610096

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