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CTSV Antibody

Datasheet
Code CSB-PA006194GA01HU
Size US$685
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Product Details

Uniprot No. O60911
Target Names CTSV
Alternative Names CAT L2 antibody; Cathepsin L2 antibody; Cathepsin U antibody; Cathepsin V antibody; CathepsinL2 antibody; CathepsinU antibody; CathepsinV antibody; CATL 2 antibody; CATL2 antibody; CATL2_HUMAN antibody; CTS L2 antibody; CTS U antibody; CTS V antibody; CTSL 2 antibody; CTSL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; PRO305 antibody; UNQ268 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human CTSL2
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cysteine protease. May have an important role in corneal physiology.
Gene References into Functions
  1. CTSV is involved in melanosome degradation. PMID: 29654760
  2. exogenous CTSV inhibited Ang -induced hypertrophy in HCM cells by inhibiting PI3K/Akt/mTOR PMID: 28522343
  3. Cathepsins V and S may serve as auxiliary diagnostic and/or prognostic markers in thymic epithelial tumors. PMID: 27771373
  4. E2F1 directly binds to CTSL2 promoter and regulates CTSL2 gene expression. PMID: 23542171
  5. using cathepsin V and cathepsin L as model enzymes, a series of chimeras were generated to identify noncatalytic regions that are responsible for the potent elastolytic activity of cathepsin V PMID: 24121514
  6. Cathepsin V expression contributes to the development of dermal fibrosis and vasculopathy in systemic sclerosis. PMID: 23287360
  7. functions of cathepsin V are controlled by N-glycosylation PMID: 22967898
  8. Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases. PMID: 22393040
  9. CTSL2 might be involved in progression of endometrial cancer. PMID: 22452389
  10. A proteolytically active variant of cathepsin V is localized to cell nucleus (in peri-nucleolar pattern) in thyroid carcinoma cells. PMID: 20536394
  11. stratum corneum thiol protease is identical with the recently described cathepsin L2 protease. PMID: 12648222
  12. Cathepsin V is involved in the degradation of invariant chain in human thymus PMID: 12925692
  13. Cathepsin V has an elastolytic activity and is expressed in activated macrophages PMID: 15192101
  14. Human cathepsin V compensates for murine cathepsin L in mouse epidermis and hair follicles. PMID: 15679121
  15. propeptide was found to behave as a tight-binding inhibitor against CatV PMID: 17516850
  16. Associated with type 1 diabetes and early-onset myasthenia gravis. PMID: 17869649
  17. angiogenesis inhibition activity on endothelial cells caused by plasminogen processing by cathepsin V PMID: 18163891

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Subcellular Location Lysosome
Protein Families Peptidase C1 family
Tissue Specificity Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
Database Links

HGNC: 2538

OMIM: 603308

KEGG: hsa:1515

STRING: 9606.ENSP00000259470

UniGene: Hs.610096
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