DLL4 Antibody

Datasheet
Code CSB-PA006949LA01HU
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Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9NR61
Image
  • Western Blot
    Positive WB detected in: HEK293 whole cell lysate
    All lanes: DLL4 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 75 kDa
    Observed band size: 75 kDa

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA006949LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunogen Recombinant Human Delta-like protein 4 protein (44-345AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200
Relevance Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4), DLL4
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Research Area Neuroscience
Target Names DLL4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the Notch signaling pathway as Notch ligand
Involvement in disease Adams-Oliver syndrome 6 (AOS6)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Expressed in vascular endothelium.
Database Links

HGNC: 2910

OMIM: 605185

KEGG: hsa:54567

STRING: 9606.ENSP00000249749

UniGene: Hs.511076

Pathway Notch signaling pathway
Th1 and Th2 cell differentiation

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