DOK6 Antibody

Code CSB-PA616052
Size US$297
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  • Western blot analysis of extracts from COLO cells, using DOK6 antibody.
  • Immunofluorescence analysis of A549 cells, using DOK6 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOK6 Polyclonal antibody
Uniprot No.
Target Names
DOK6
Alternative Names
DOK6 antibody; DOK5LDocking protein 6 antibody; Downstream of tyrosine kinase 6 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human DOK6.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Gene References into Functions
  1. DOK-6 is involved in RET signaling with less influence when compared with DOK-1, DOK-4, and SHC. PMID: 20210798
  2. Dok-6 binds to the phosphorylated Ret Tyr(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism PMID: 15286081
Protein Families
DOK family, Type B subfamily
Tissue Specificity
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
Database Links

HGNC: 28301

OMIM: 611402

KEGG: hsa:220164

STRING: 9606.ENSP00000372160

UniGene: Hs.278285

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