ECSIT Antibody

Code CSB-PA859414ESR2HU
Size US$166
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Image
  • Western blot
    All lanes: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial antibody at 10μg/ml + Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 50, 34, 25 kDa
    Observed band size: 50 kDa

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA859414ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA859414ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ECSIT Polyclonal antibody
Uniprot No.
Target Names
ECSIT
Alternative Names
Ecsit antibody; ECSIT homolog antibody; ECSIT protein antibody; ECSIT_HUMAN antibody; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial antibody; Evolutionarily conserved signaling intermediate in Toll pathways antibody; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved antibody; Protein SITPEC antibody; Signaling intermediate in Toll pathway evolutionarily conserved antibody; SITPEC antibody; SITPEC protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Gene References into Functions
  1. mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex PMID: 25228397
  2. Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. PMID: 25355951
  3. Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. PMID: 25449573
  4. Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6), plays a role in Toll-like receptor 4 -mediated signals to activate NF-kappa B. PMID: 25371197
  5. TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. PMID: 22588174

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Subcellular Location
Cytoplasm. Nucleus. Mitochondrion.
Protein Families
ECSIT family
Database Links

HGNC: 29548

OMIM: 608388

KEGG: hsa:51295

STRING: 9606.ENSP00000270517

UniGene: Hs.515146

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