ECSIT Antibody

Datasheet

Code	CSB-PA859414ESR2HU
Size	US$166
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Image	Western blot All lanes: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial antibody at 10μg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 50, 34, 25 kDa Observed band size: 50 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA859414ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA859414ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ECSIT Polyclonal antibody

Uniprot No.

Q9BQ95

Target Names

ECSIT

Alternative Names

Ecsit antibody; ECSIT homolog antibody; ECSIT protein antibody; ECSIT_HUMAN antibody; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial antibody; Evolutionarily conserved signaling intermediate in Toll pathways antibody; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved antibody; Protein SITPEC antibody; Signaling intermediate in Toll pathway evolutionarily conserved antibody; SITPEC antibody; SITPEC protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.

Gene References into Functions

mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex PMID: 25228397
Ubiquitination of ECSIT might have a role in the regulation of NF-kappaB activity in TLR4 signaling. PMID: 25355951
Authors conclude that ECSIT appears to be a novel Hepatitis B virus X protein-interacting signal molecule and their interaction is mechanistically important in IL-1beta induction of NF-kappaB activation. PMID: 25449573
Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6), plays a role in Toll-like receptor 4 -mediated signals to activate NF-kappa B. PMID: 25371197
TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. PMID: 22588174

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Subcellular Location

Cytoplasm. Nucleus. Mitochondrion.

Protein Families

ECSIT family

Database Links

HGNC: 29548

OMIM: 608388

KEGG: hsa:51295

STRING: 9606.ENSP00000270517

UniGene: Hs.515146

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

MAPK signaling pathway Virus Infection

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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