EFNB3 Antibody

Datasheet

Code	CSB-PA007467ESR1HU
Size	US$166
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Image	Western blot All lanes: EFNB3 antibody at 1.44μg/ml Lane 1: HepG2 whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA007467ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EFNB3 Polyclonal antibody

Uniprot No.

Q15768

Target Names

EFNB3

Alternative Names

EFL 6 antibody; EFL6 antibody; EFNB 3 antibody; Efnb3 antibody; EFNB3_HUMAN antibody; EPH related receptor transmembrane ligand ELK L3 antibody; EPH related receptor transmembrane ligand ELKL3 antibody; EPH related receptor tyrosine kinase ligand 8 antibody; EPH-related receptor transmembrane ligand ELK-L3 antibody; EPH-related receptor tyrosine kinase ligand 8 antibody; Ephrin B3 antibody; Ephrin-B3 antibody; EphrinB3 antibody; EPLG 8 antibody; EPLG8 antibody; LERK 8 antibody; LERK-8 antibody; LERK8 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ephrin-B3 protein (28-226AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.; (Microbial infection) Acts as a receptor for nipah virus and hendra virus.

Gene References into Functions

The study provides evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrating that EFNB3 is a hypertension risk gene. PMID: 28272517
Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation. PMID: 27941904
Data show that Ephrin B3 was concomitantly expressed with EphA2 and Ephrin A1 with higher Ephrin B3 levels found in non-squamous than in squamous tumors. PMID: 27533087
Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy PMID: 26930615
Findings suggest that EphrinB3 may be a relevant target for promoting remyelination in demyelinating disease PMID: 26687980
Ephrin-B3 binds to B lymphocytes, most likely via a non-classical receptor, and induces migration of the memory B cell subpopulation. PMID: 21447033
Phosphoproteomic profiling of nonsmall cell lung cancer cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. PMID: 21413766
evidence for an unknown ephrin-B3-binding cell-surface proteoglycan involved in cellular signalling PMID: 20925654
EphrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity. PMID: 16477309
Immunohistochemistry shows robust staining for phosphorylated ephrin-B and ephrin-B3 in invading glioblastoma cells. PMID: 16951161
Transgenic EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus PMID: 18057206
report the crystal structures of the NiV-G both in its receptor-unbound state and in complex with ephrin-B3, providing, to our knowledge, the first view of a paramyxovirus attachment complex in which a cellular protein is used as the virus receptor PMID: 18632560

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Ephrin family

Tissue Specificity

Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.

Database Links

HGNC: 3228

OMIM: 602297

KEGG: hsa:1949

STRING: 9606.ENSP00000226091

UniGene: Hs.26988

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Protein Service

Gene Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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