Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ENOX2 Polyclonal antibody

Uniprot No.

Q16206

Target Names

ENOX2

Alternative Names

APK1 antibody; APK1 antigen antibody; COVA1 antibody; Cytosolic ovarian carcinoma antigen 1 antibody; Ecto NOX disulfide thiol exchanger 2 antibody; ENOX 2 antibody; ENOX2 antibody; ENOX2_HUMAN antibody; OTTHUMP00000024021 antibody; OTTHUMP00000024022 antibody; Protein disulfide-thiol oxidoreductase antibody; tNOX antibody; Tumor associated hydroquinone oxidase antibody; Tumor-associated hydroquinone oxidase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ecto-NOX disulfide-thiol exchanger 2 protein (411-610AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
Gene References into Functions	The tumor-associated NADH oxidase (tNOX)-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis. PMID: 28122359 These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID: 27271588 The findings support a role for arNOX as a major source of oxidative damage leading to cross-linking of skin proteins. PMID: 24906676 The results suggest that phosphorylation of serine-504 by PKCdelta modulates the biological function of tNOX. PMID: 22659163 this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959 increased NADH levels resulting from ENOX2 inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 inhibitor-induced apoptotic cascade. PMID: 21571040 ENOX2 is a dimeric protein containing 4 coppers/dimer capable of carrying out concerted four electron transfers from NADH or ubiquinol to molecular oxygen as required to form water. PMID: 20922471 arNOX activity correlates with age and reaches a maximum at about age 65 in males and 55 in females. PMID: 20345278 Enhanced arNOX activity correlates with age and with oxidative changes contributing to skin aging. PMID: 19734125 tNOX is both necessary and sufficient for the cellular anticancer activities attributed to both EGCg and capsaicin. *tNOX enzyme PMID: 15706060 results indicate that shRNA targeting of tNOX inhibits the growth of cervical cancer cells, and reduces cell migration via a decrease in the membrane association of Rac. PMID: 18023414 A relationship of tNOX to unregulated growth of cancer cells was provided by data where growth of HeLa cells was inhibited by transfection with the exon 5 antisense oligonucleotides PMID: 18351130 These results indicate that tNOX is suppressed during apoptosis and demonstrate that tNOX down-regulation sensitizes cells to stress-induced growth reduction, suggesting that tNOX is required for transformed cell growth. PMID: 18789934 Show More Hide All
Subcellular Location	Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
Protein Families	ENOX family
Tissue Specificity	Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed in
Database Links	HGNC: 2259 OMIM: 300282 KEGG: hsa:10495 STRING: 9606.ENSP00000337146 UniGene: Hs.171458

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Check Code：

Code	CSB-PA007677ESR1HU
Size	US$299 How to order?
Image	Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA007677ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA007677ESR1HU at dilution of 1:100
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ENOX2 Antibody

Product Details

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Target Background

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