ETFA Antibody

Code CSB-PA007844ESR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: ETFA antibody at 2.88µg/ml
    Lane 1: Mouse small intestine tissue
    Lane 2: Mouse liver tissue
    Lane 3: A431 whole cell lysate
    Lane 4: Hela whole cell lysate
    Lane 5: K562 whole cell lysate
    Lane 6: A549 whole cell lysate
    Lane 7: HepG2 whole cell lysate
    Lane 8: MCF-7 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 36, 31 kDa
    Observed band size: 36 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007844ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA007844ESR2HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ETFA Polyclonal antibody
Uniprot No. P13804
Target Names ETFA
Alternative Names Alpha ETF antibody; Alpha-ETF antibody; Electron transfer flavoprotein alpha polypeptide antibody; Electron transfer flavoprotein alpha subunit antibody; Electron transfer flavoprotein subunit alpha mitochondrial antibody; Electron transfer flavoprotein subunit alpha; mitochondrial antibody; Electron transferring flavoprotein alpha polypeptide antibody; EMA antibody; ETFA antibody; ETFA_HUMAN antibody; GA2 antibody; Glutaric aciduria II antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Electron transfer flavoprotein subunit alpha, mitochondrial protein (1-333AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase
Gene References into Functions
  1. Data suggest that ETF (heterodimer of ETFA and ETFB) catalyzes irreversible and pH-dependent oxidation of 8alpha-methyl group of FAD to form to 8-formyl-FAD (8f-FAD). PMID: 29301933
  2. our results indicate that genetic variants in ETFA may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the ETFA genes in the occurrence of glioma. PMID: 28320150
  3. the mechanism of tert-butyl hydroperoxide-induced an apoptosis cascade and endoplasmic reticulum stress in hepatocyte cells by up-regulation of ETFA, providing a new mechanism for liver injury. PMID: 24394546
  4. These results are consistent with the electron transfer flavoprotein alpha II domain adopting orientations in solution that deviate from the crystal structure of free ETF towards the active, substrate-bound orientation. PMID: 21308847
  5. investigations are compatible with the notion that the ETFalpha-T171 variant displays an altered conformational landscape that results in reduced protein function under thermal stress PMID: 21219902
  6. Data established structural hotspots within the ETF fold, and provided a rationale for the prediction of effects of mutations in ETF. PMID: 20674745
  7. These studies indicate that a series of conformational changes occur during the assembly of the TMADH.ETF electron transfer complex and that the kinetics of assembly observed with mutant TMADH or ETF complexes are much slower PMID: 11756429
  8. Tissue samples from 16 unrelated patients with ETF deficiency were analysed and the majority of the patients had mutations in the ETFA gene. PMID: 16510302
  9. No mutations in electron-transfer-flavoprotein but maternal riboflavin deficiency led to multiple acyl-CoA dehydrogenation deficiency PMID: 17689999

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Involvement in disease Glutaric aciduria 2A (GA2A)
Subcellular Location Mitochondrion matrix
Protein Families ETF alpha-subunit/FixB family
Database Links

HGNC: 3481

OMIM: 231680

KEGG: hsa:2108

STRING: 9606.ENSP00000452762

UniGene: Hs.39925

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