FBXO6 Antibody

Datasheet

Code	CSB-PA008515GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NRD1

Target Names

FBXO6

Alternative Names

F box protein that recognizes sugar chains 2 antibody; F box G domain protein 2 antibody; F box only protein 6 antibody; F box protein 6 antibody; F box protein FBG2 antibody; F box protein Fbx6 antibody; F box/G domain protein 2 antibody; F-box only protein 6 antibody; F-box protein that recognizes sugar chains 2 antibody; F-box/G-domain protein 2 antibody; FBG 2 antibody; FBG2 antibody; FBS 2 antibody; FBS2 antibody; FBX 6 antibody; FBX6 antibody; FBX6_HUMAN antibody; FBXO 6 antibody; FBXO6 antibody; OTTHUMP00000002267 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human FBXO6

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Gene References into Functions

FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis. PMID: 27855403
It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. PMID: 25374377
systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions. PMID: 22268729
Two interacting proteins of human FBXO6 protein have been found using the service in the study. PMID: 22292078
Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD PMID: 12939278
Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. PMID: 19716789

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Subcellular Location

Cytoplasm.

Database Links

HGNC: 13585

OMIM: 605647

KEGG: hsa:26270

STRING: 9606.ENSP00000365944

UniGene: Hs.464419

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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