F-box only protein 6 is a protein in humans that is encoded by FBXO6 gene. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
The following FBXO6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FBXO6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008515GA01HU | FBXO6 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA873634ESR1HU | FBXO6 Antibody |
Human | ELISA, WB, IHC |
CSB-PA873634ESR2HU | FBXO6 Antibody |
Human | ELISA, IHC |
FBXO6 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP664851BO CSB-EP664851BO CSB-BP664851BO CSB-MP664851BO CSB-EP664851BO-B |
Recombinant Bovine F-box only protein 6 (FBXO6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP846061RA CSB-EP846061RA CSB-BP846061RA CSB-MP846061RA CSB-EP846061RA-B |
Recombinant Rat F-box only protein 6 (Fbxo6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP870789MO CSB-EP870789MO CSB-BP870789MO CSB-MP870789MO CSB-EP870789MO-B |
Recombinant Mouse F-box only protein 6 (Fbxo6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP873634HU CSB-EP873634HU CSB-BP873634HU CSB-MP873634HU CSB-EP873634HU-B |
Recombinant Human F-box only protein 6 (FBXO6) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |