FCGRT Antibody, FITC conjugated

^{Rare Species}

Datasheet

Code	CSB-PA851443LC01MOV
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) FCGRT Polyclonal antibody

Uniprot No.

Q8SPV9

Target Names

FCGRT

Alternative Names

FCGRT antibody; FCRNIgG receptor FcRn large subunit p51 antibody; FcRn antibody; IgG Fc fragment receptor transporter alpha chain antibody; Neonatal Fc receptor antibody

Raised in

Rabbit

Species Reactivity

Macaca fascicularis

Immunogen

Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA)

Immunogen Species

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.

Gene References into Functions

None of the non-synonymous variants of FCGRT or B2M found changes in the amino acid residues known to be important for FcRn function, suggesting that substantial inter-animal variability of FcRn is not expected for the cynomolgus macaques analyzed PMID: 24806819
Characterization and screening of IgG binding to the neonatal Fc receptor. PMID: 24802048

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endosome membrane.

Protein Families

Immunoglobulin superfamily

Database Links

KEGG: mcf:102128913

UniGene: Mfa.8387

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Phage Display Service

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Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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