FCGRT, also known as neonatal Fc receptor, is a heterodimer composed of α heavy chain and β2-microglobulin. It has unique structural characteristics and can specifically bind to the Fc-terminal CH2–CH3 hinge region of IgG. This binding is pH-dependent, with binding occurring under acidic conditions and dissociation occurring under neutral and weakly alkaline conditions. FCGRT plays a key role in the immune system, including mediating the specific transport of IgG, maintaining the levels of IgG and serum albumin in the serum, and protecting IgA in mucosal tissues. Its binding process with IgG is pH-dependent. Under acidic conditions, pH6.0-6.5, FCGRT binds to IgG; while under neutral and weakly alkaline conditions, pH7.0-7.5, dissociation occurs. In addition, the binding of FCGRT to IgG is through the Fc-terminal CH2–CH3 hinge region of IgG, and the binding site of FcRn to IgG is different from that of serum albumin, so the binding of FcRn to IgG is not affected by serum proteins.
The following FCGRT reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FCGRT Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008545EC01HU | FCGRT Antibody, FITC conjugated |
Human | |
CSB-PA008545EB01HU | FCGRT Antibody, HRP conjugated |
Human | ELISA |
CSB-PA008545EA01HU | FCGRT Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA008545GA01HU | FCGRT Antibody |
Human | ELISA,WB |
FCGRT Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP008545HU | Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial |
E.coli |
CSB-EP008545HU-B |
Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT) |
In Vivo Biotinylation in E.coli |
CSB-YP008545HU | Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial |
Yeast |
CSB-MP008545HU | Recombinant Human IgG receptor FcRn large subunit p51 (FCGRT), partial |
Mammalian cell |
FCGRT ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL008545HU | Human IgG receptor FcRn large subunit p51(FCGRT) ELISA kit |
serum, plasma, tissue homogenates | 3.9 pg/mL |