FCGRT Antibody, HRP conjugated

Code CSB-PA851443LB01MOV
Size US$166
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Product Details

Full Product Name
Rabbit anti-Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) FCGRT Polyclonal antibody
Uniprot No.
Target Names
FCGRT
Alternative Names
FCGRT antibody; FCRNIgG receptor FcRn large subunit p51 antibody; FcRn antibody; IgG Fc fragment receptor transporter alpha chain antibody; Neonatal Fc receptor antibody
Raised in
Rabbit
Species Reactivity
Macaca fascicularis
Immunogen
Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA)
Immunogen Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
Gene References into Functions
  1. None of the non-synonymous variants of FCGRT or B2M found changes in the amino acid residues known to be important for FcRn function, suggesting that substantial inter-animal variability of FcRn is not expected for the cynomolgus macaques analyzed PMID: 24806819
  2. Characterization and screening of IgG binding to the neonatal Fc receptor. PMID: 24802048
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Protein Families
Immunoglobulin superfamily
Database Links

KEGG: mcf:102128913

UniGene: Mfa.8387

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