FDPS Antibody

Datasheet
Code CSB-PA008563LA01HU
See More Details Free Antibody trial simple
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate
    All lanes: FDPS antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 49, 41 kDa
    Observed band size: 41 kDa

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA008563LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008563LA01HU at dilution of 1:100

  • Immunoprecipitating FDPS in HepG2 whole cell lysate
    Lane 1: Rabbit control IgG (1µg) instead of CSB-PA008563LA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
    Lane 2: CSB-PA008563LA01HU (8µg) + HepG2 whole cell lysate (500µg)
    Lane 3: HepG2 whole cell lysate (10µg)

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) FDPS Polyclonal antibody
Uniprot No. P14324
Target Names FDPS
Alternative Names Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase), FDPS, FPS KIAA1293
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Farnesyl pyrophosphate synthase protein (1-419AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IP
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IP 1:200-1:2000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Citations

Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. Qingzhu Liu, et al,European Journal of Medicinal Chemistry,2019

Sample type: Cancer cell lines
Sample species: Human
Antibody dilution factor: 1:2000
Application: WB
Review: Western blot analysis of FPPS expression in various types of cancer cell lines, including colorectal cancers (HCT116, LoVo), breast cancers (MDA-MB-231, MDA-MB-468, MCF-7), prostate cancer (PC-3), liver cancer (HepG2), and ovarian cancer (SKOV-3).

Target Data

Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Involvement in disease Porokeratosis 9, multiple types (POROK9)
Subcellular Location Cytoplasm
Protein Families FPP/GGPP synthase family
Database Links

HGNC: 3631

OMIM: 134629

KEGG: hsa:2224

STRING: 9606.ENSP00000349078

UniGene: Hs.335918

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